Medical radioisotopes save an incredibly large number of lives. However, the safety, security and efficiency of the logistics and supply chain are the key-points of medical radioisotopes delivery and use. Securing their inventory, preventing their loss or any theft are the key points. Optimizing the full chain, managing availability, potential penuries, distances between radioisotope suppliers and hospitals, is mandatory. The same applies to waste management and disposal after use. Although strict procedures are followed to enforce compliance to regulations, an integrated and ubiquitous solution greatly increases trust and efficiency of the complete medical radioisotope cycle, while drastically reducing costs.